Dr Stephen Eglen
- 1997-2000 Wellcome Trust Fellow in Mathematical Biology, Edinburgh
- 2000-2001 Lecturer, School of Informatics, Edinburgh
- 2001-2004 Wellcome Trust Travelling Fellowship, St Louis and Edinburgh
- 2004-2006 Lecturer, DAMTP
- 2006- Senior Lecturer, DAMTP
Stephen Eglen is a computational neuroscientist: he uses computational methods to study the development of the nervous system, using mostly the retina and other parts of the visual pathway as a model system. He is particularly interested in questions of structural and functional development:
Structural development: how do retinal neurons acquire their positional information within a circuit?
Functional development: what are the mechanisms by which neurons make contact with each other, to perform functioning circuits?
- SJ Eglen, DD Lofgreen, MA Raven, BE Reese (2008). Analysis of spatial relationships in three dimensions: tools for the study of nerve cell patterning. BMC Neuroscience 9:68
- SJ Eglen, JCT Wong (2008). Spatial constraints underlying the retinal mosaics of two types of horizontal cells in cat and macaque. Visual Neuroscience 25:209-214.
- SJ Eglen (2006). Development of regular cellular spacing in the retina: theoretical models. Mathematical Medicine and Biology 23:79-99.
- PJ Diggle, SJ Eglen, JB Troy (2006). Modelling the bivariate spatial distribution of amacrine cells. In A. Baddeley et al. (Eds.) Case Studies in Spatial Point Process Modelling, Springer Lecture notes in Statistics 185:215--233.
- SJ Eglen, PJ Diggle, JB Troy (2005). Homotypic constraints dominate positioning of on- and off-centre beta retinal ganglion cells Visual Neuroscience 22:859--871.
- M Kishi, TT Kummer, SJ Eglen, JR Sanes (2005). LL5 beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction. Journal of Cell Biology 169:355-366.
- SJ Eglen, J Demas, ROL Wong (2003) Mapping by waves: patterned spontaneous activity regulates retinotopic map refinement. Neuron 40:1053-1055.
- SJ Eglen, MA Raven, E Tamrazian, BE Reese (2003) Dopaminergic amacrine cells in the inner nuclear layer and ganglion cell layer comprise a single functional retinal mosaic J. Comp. Neurol. 466: 343-355.
- E Sernagor, C Young, SJ Eglen (2003) Developmental Modulation of Retinal Wave Dynamics: Shedding Light on the GABA Saga. J Neurosci. 23:7621--7629.
- MA Raven, SJ Eglen, JJ Ohab, BE Reese (2003) Determinants of the exclusion zone in dopaminergic amacrine cell mosaics. J Comp. Neurol. 461:123-136.
- J Demas, SJ Eglen, ROL Wong (2003) Developmental loss of synchronous spontaneous activity in the mouse retina is independent of visual experience. J Neurosci. 23:2851-2860.
- SJ Eglen, DJ Willshaw (2002) Influence of cell fate mechanisms upon retinal mosaic formation: a modelling study. Development 129:5399-5408.
- CW Lee, SJ Eglen, ROL Wong (2002) Segregation of on and off retinogeniculate connectivity directed by patterned spontaneous activity. J Neurophysiol. 88:2311-2321.
- E Sernagor, SJ Eglen, and ROL Wong (2001) Development of retinal ganglion cell structure and function. Progress in Retinal and Eye Research 20:139-174.
- SJ Eglen, A van Ooyen, DJ Willshaw (2000) Lateral cell movement driven by dendritic interactions is sufficient to form retinal mosaics. Network 11:103-118.
- E Sernagnor, SJ Eglen, MJ O'Donovan (2000) Differential effects of acetylcholine and glutamate blockade on the spatiotemporal dynamics of retinal waves. J Neurosci 20:RC56(1-6).