Dr Francesco Boselli

Career

2016-present: Postdoctoral researcher, DAMTP, University of Cambridge, UK
2013-2015: Postdoctoral researcher, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Strasbourg, France
2008-2012: Doctoral student and teaching assistent, Institue of Fluid Dynamics, ETH Zurich, Zurich, CH
2007 (summar intership): Graduate researcher, Learner Research Institute, Cleveland Clinic Foundation, Cleveland, USA
2007-2006 Bachelor/Master student (biomedical engineering), Politecnico di Milano, Milano, Italy

Research

I am a member of the Biological Physics research group in the Department of Applied Mathematics and Theoretical Physics (DAMTP). I am interested in the role of fluid flows and forces in the regulation and development of biological systems.

keywords: Cilia, Biological Stokesian Flows, Mechanotransduction, heart/valve development, embyonic heart, blood flow, inner ear, Benigne Paroxismal Positional Vertigo (BPPV), boundary and meshless numerical methods.

Links to Publications

Publications

CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.

T Ochi, V Quarantotti, H Lin, J Jullien, I Rosa E Silva, F Boselli, DD Barnabas, CM Johnson, SH McLaughlin, SMV Freund, AN Blackford, Y Kimata, RE Goldstein, SP Jackson, TL Blundell, SK Dutcher, F Gergely, M van Breugel

– Structure

(2020)

28,

674

(DOI: 10.1016/j.str.2020.04.010)

Blood Flow Limits Endothelial Cell Extrusion in the Zebrafish Dorsal Aorta.

P Campinho, P Lamperti, F Boselli, A Vilfan, J Vermot

– Cell Reports

(2020)

31,

107505

(DOI: 10.1016/j.celrep.2020.03.069)

Three-dimensional microscopy and image analysis methodology for mapping and quantification of nuclear positions in tissues with approximate cylindrical geometry.

P Campinho, P Lamperti, F Boselli, J Vermot

– Philosophical transactions of the Royal Society of London. Series B, Biological sciences

(2018)

373,

20170332

(DOI: 10.1098/rstb.2017.0332)

Following endocardial tissue movements via cell photoconversion in the zebrafish embryo

RW-Y Chow, P Lamperti, E Steed, F Boselli, J Vermot

– Journal of Visualized Experiments

(2018)

2018,

ARTN e57290

(DOI: 10.3791/57290)

Anisotropic shear stress patterns predict the orientation of convergent tissue movements in the embryonic heart.

F Boselli, E Steed, JB Freund, J Vermot

– Development (Cambridge)

(2017)

144,

4322

(DOI: 10.1242/dev.152124)

Hemodynamics driven cardiac valve morphogenesis.

E Steed, F Boselli, J Vermot

– Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

(2016)

1863,

1760

(DOI: 10.1016/j.bbamcr.2015.11.014)

Live imaging and modeling for shear stress quantification in the embryonic zebrafish heart.

F Boselli, J Vermot

– Methods (San Diego, Calif.)

(2016)

94,

129

(DOI: 10.1016/j.ymeth.2015.09.017)

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies.

C Ramspacher, E Steed, F Boselli, R Ferreira, N Faggianelli, S Roth, C Spiegelhalter, N Messaddeq, L Trinh, M Liebling, N Chacko, F Tessadori, J Bakkers, J Laporte, K Hnia, J Vermot

– Cell reports

(2015)

11,

1564

(DOI: 10.1016/j.celrep.2015.05.010)

Oscillatory flow modulates mechanosensitive klf2a expression through trpv4 and trpp2 during heart valve development

E Heckel, F Boselli, S Roth, A Krudewig, H-G Belting, G Charvin, J Vermot

– Curr Biol

(2015)

25,

1354

(DOI: 10.1016/j.cub.2015.03.038)

Blood flow mechanics in cardiovascular development

F Boselli, JB Freund, J Vermot

– Cellular and molecular life sciences : CMLS

(2015)

72,

2545

(DOI: 10.1007/s00018-015-1885-3)

Department of Applied Mathematics and Theoretical Physics

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