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Career

  •  2018-date: Royal Society E.P. Abraham Professor, DAMPT, Cambridge
  • 2011-date: Herchel Smith Chair in Physics, Cavendish Laboratory,
  • Cambridge
  • 2002-2010: Personal Chair in the Theory of Condensed Matter, Cavendish Laboratory,
  • Cambridge
  • 2000-2002: University Readership in the Theory of Condensed Matter, Cavendish Laboratory, Cambridge
  • 1995-1999: Lecturer, Cavendish Laboratory, Cambridge
  • 1995-date: Fellow, St John’s College, Cambridge
  • 1994-1995: Royal Society Research Fellow and Lecturer, Imperial College, London
  • 1990-1991: Junior Research Fellow, Gonville and Caius College, Cambridge

Research

Ben is a member the Department of Applied Mathematics and Theoretical Physics and the Cavendish Laboratory, Department of Physics. He also holds affiliated positions in the Wellcome Trust/CRUK Gurdon Institute and the Wellcome Trust/MRC Stem Cell Institute. His research interests have spanned a wide range of topics within the area of theoretical quantum condensed matter physics. However, his current interests are focussed on the application of modelling approaches to study the dynamics of biological systems, from subcellular processes, to cell fate decision-making and morphogenic processes. His research is supported by grants from EPSRC, the Wellcome Trust, CRUK and the Royal Society.

Selected Publications

  • S. Rulands, et al., Universality of clone dynamics during tissue development, Nature Physics 14, 469-474 (2018)
  • E. Hannezo, et al., A unifying theory of branching morphogenesis, Cell 171, 242-255 (2017)
  • X. Lan, et al., Cell fate mapping of human glioblastoma reveals an invariant stem cell hierarchy pre- and post-treatment, Nature 549, 227-232 (2017)
  • A. Sanchez-Danes, et al., Defining the clonal dynamics leading to tumor initiation, Nature 536, 298-303 (2016)
  • B. D. Simons and H. Clevers, Strategies of stem cell self-renewal in adult tissues, Cell 145, 851-862 (2011)
  • C. Lopez-Garcia, et al., Intestinal stem cell replacement follows a pattern of neutral drift, Science 330, 822-825 (2010)

Publications

REPLY TO MARTINCORENA ET AL.: Evidence for constrained positive selection of cancer mutations in normal skin is lacking
BD Simons
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
113,
E1130
Uncovering the Number and Clonal Dynamics of Mesp1 Progenitors during Heart Morphogenesis.
S Chabab, F Lescroart, S Rulands, N Mathiah, BD Simons, C Blanpain
– Cell reports
(2015)
14,
1
Deep sequencing as a probe of normal stem cell fate and preneoplasia in human epidermis
BD Simons
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
113,
128
Human keratinocytes have two interconvertible modes of proliferation.
A Roshan, K Murai, J Fowler, BD Simons, V Nikolaidou-Neokosmidou, PH Jones
– Nature Cell Biology
(2015)
18,
145
Stem and progenitor cell division kinetics during postnatal mouse mammary gland development.
RR Giraddi, M Shehata, M Gallardo, MA Blasco, BD Simons, J Stingl
– Nat Commun
(2015)
6,
8487
Dynamics of Lgr6+ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis
A Füllgrabe, S Joost, A Are, T Jacob, U Sivan, A Haegebarth, S Linnarsson, BD Simons, H Clevers, R Toftgård, M Kasper
– Stem cell reports
(2015)
5,
843
The Independent Probabilistic Firing of Transcription Factors: A Paradigm for Clonal Variability in the Zebrafish Retina.
H Boije, S Rulands, S Dudczig, BD Simons, WA Harris
– Developmental cell
(2015)
34,
532
Cell Competition Modifies Adult Stem Cell and Tissue Population Dynamics in a JAK-STAT-Dependent Manner.
G Kolahgar, SJE Suijkerbuijk, I Kucinski, EZ Poirier, S Mansour, BD Simons, E Piddini
– Dev Cell
(2015)
34,
297
Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium
JK Watson, S Rulands, AC Wilkinson, A Wuidart, M Ousset, A Van Keymeulen, B Göttgens, C Blanpain, BD Simons, EL Rawlins
– Cell Rep
(2015)
12,
90
Fluctuation and commensurability effect of exciton density wave
S Yang, LV Butov, BD Simons, KL Campman, AC Gossard
– Physical Review B Condensed Matter and Materials Physics
(2015)
91,
245302
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Research Group

Biological Physics and Mechanics

Room

H1.13

Telephone

01223 766833