Dr Francesco Boselli | Department of Applied Mathematics and Theoretical Physics

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Career

2016-present: Postdoctoral researcher, DAMTP, University of Cambridge, UK
2013-2015: Postdoctoral researcher, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Strasbourg, France
2008-2012: Doctoral student and teaching assistent, Institue of Fluid Dynamics, ETH Zurich, Zurich, CH
2007 (summar intership): Graduate researcher, Learner Research Institute, Cleveland Clinic Foundation, Cleveland, USA
2007-2006 Bachelor/Master student (biomedical engineering), Politecnico di Milano, Milano, Italy

Research

I am a member of the Biological Physics research group in the Department of Applied Mathematics and Theoretical Physics (DAMTP). I am interested in the role of fluid flows and forces in the regulation and development of biological systems.

keywords: Cilia, Biological Stokesian Flows, Mechanotransduction, heart/valve development, embyonic heart, blood flow, inner ear, Benigne Paroxismal Positional Vertigo (BPPV), boundary and meshless numerical methods.

Links to Publications

Publications

Oscillatory flow modulates mechanosensitive klf2a expression through trpv4 and trpp2 during heart valve development

E Heckel, F Boselli, S Roth, A Krudewig, H-G Belting, G Charvin, J Vermot

– Current Biology

(2015)

25,

1354

(DOI: 10.1016/j.cub.2015.03.038)

Blood flow mechanics in cardiovascular development.

F Boselli, JB Freund, J Vermot

– Cellular and Molecular Life Sciences

(2015)

72,

2545

(DOI: 10.1007/s00018-015-1885-3)

Chapter 8 A quantitative approach to study endothelial cilia bending stiffness during blood flow mechanodetection in vivo

F Boselli, JG Goetz, G Charvin, J Vermot

– Methods in cell biology

(2015)

127,

161

(DOI: 10.1016/bs.mcb.2015.01.006)

Quantitative analysis of benign paroxysmal positional vertigo fatigue under canalithiasis conditions.

F Boselli, L Kleiser, CJ Bockisch, SCA Hegemann, D Obrist

– J Biomech

(2014)

47,

1853

(DOI: 10.1016/j.jbiomech.2014.03.019)

Endothelial Cilia Mediate Low Flow Sensing during Zebrafish Vascular Development

JG Goetz, E Steed, RR Ferreira, S Roth, C Ramspacher, F Boselli, G Charvin, M Liebling, C Wyart, Y Schwab, J Vermot

– Cell reports

(2014)

6,

799

(DOI: 10.1016/j.celrep.2014.01.032)

A meshless boundary method for Stokes flows with particles: application to canalithiasis.

F Boselli, D Obrist, L Kleiser

– International journal for numerical methods in biomedical engineering

(2013)

29,

1176

(DOI: 10.1002/cnm.2564)

A multilayer method of fundamental solutions for Stokes flow problems

F Boselli, D Obrist, L Kleiser

– J. Comput. Phys.

(2012)

231,

6139

(DOI: 10.1016/j.jcp.2012.05.023)

Vortical flow in the utricle and the ampulla: a computational study on the fluid dynamics of the vestibular system.

F Boselli, D Obrist, L Kleiser

– Biomech Model Mechanobiol

(2012)

12,

335

(DOI: 10.1007/s10237-012-0402-y)