Career
- 2018-date: Royal Society E.P. Abraham Professor, DAMPT, Cambridge
- 2011-date: Herchel Smith Chair in Physics, Cavendish Laboratory,
- Cambridge
- 2002-2010: Personal Chair in the Theory of Condensed Matter, Cavendish Laboratory,
- Cambridge
- 2000-2002: University Readership in the Theory of Condensed Matter, Cavendish Laboratory, Cambridge
- 1995-1999: Lecturer, Cavendish Laboratory, Cambridge
- 1995-date: Fellow, St John’s College, Cambridge
- 1994-1995: Royal Society Research Fellow and Lecturer, Imperial College, London
- 1990-1991: Junior Research Fellow, Gonville and Caius College, Cambridge
Research
Ben is a member the Department of Applied Mathematics and Theoretical Physics and the Cavendish Laboratory, Department of Physics. He also holds affiliated positions in the Wellcome Trust/CRUK Gurdon Institute and the Wellcome Trust/MRC Stem Cell Institute. His research interests have spanned a wide range of topics within the area of theoretical quantum condensed matter physics. However, his current interests are focussed on the application of modelling approaches to study the dynamics of biological systems, from subcellular processes, to cell fate decision-making and morphogenic processes. His research is supported by grants from EPSRC, the Wellcome Trust, CRUK and the Royal Society.
Selected Publications
- S. Rulands, et al., Universality of clone dynamics during tissue development, Nature Physics 14, 469-474 (2018)
- E. Hannezo, et al., A unifying theory of branching morphogenesis, Cell 171, 242-255 (2017)
- X. Lan, et al., Cell fate mapping of human glioblastoma reveals an invariant stem cell hierarchy pre- and post-treatment, Nature 549, 227-232 (2017)
- A. Sanchez-Danes, et al., Defining the clonal dynamics leading to tumor initiation, Nature 536, 298-303 (2016)
- B. D. Simons and H. Clevers, Strategies of stem cell self-renewal in adult tissues, Cell 145, 851-862 (2011)
- C. Lopez-Garcia, et al., Intestinal stem cell replacement follows a pattern of neutral drift, Science 330, 822-825 (2010)
Publications
Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency
– Cell Syst
(2018)
7,
63
(doi: 10.1016/j.cels.2018.06.012)
Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland
– Nature cell biology
(2018)
20,
677
(doi: 10.1038/s41556-018-0108-1)
The developmental origin of brain tumours: a cellular and molecular framework
– Development Cambridge
(2018)
145,
dev162693
(doi: 10.1242/dev.162693)
Predominant asymmetrical stem cell fate outcome limits the rate of niche succession in human colonic crypts
– Ebiomedicine
(2018)
31,
166
(doi: 10.1016/j.ebiom.2018.04.017)
A niche of trophoblast progenitor cells identified 1 by integrin α2 is 2 present in first trimester human placentas
– Development Cambridge
(2018)
145,
dev162305
(doi: 10.1242/dev.162305)
Universality of clone dynamics during tissue development
– Nature physics
(2018)
14,
523
(doi: 10.1038/s41567-018-0055-6)
Live imaging of neurogenesis in the adult mouse hippocampus
– Science
(2018)
359,
658
(doi: 10.1126/science.aao5056)
Defining murine organogenesis at single cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation
– Nat Cell Biol
(2018)
20,
127
(doi: 10.1038/s41556-017-0013-z)
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
E610
(doi: 10.1073/pnas.1715911114)
Muscle Stem Cells Exhibit Distinct Clonal Dynamics in Response to Tissue Repair and Homeostatic Aging.
– Cell stem cell
(2017)
22,
119
(doi: 10.1016/j.stem.2017.11.009)
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