Career
- 2018-date: Royal Society E.P. Abraham Professor, DAMPT, Cambridge
- 2011-date: Herchel Smith Chair in Physics, Cavendish Laboratory,
- Cambridge
- 2002-2010: Personal Chair in the Theory of Condensed Matter, Cavendish Laboratory,
- Cambridge
- 2000-2002: University Readership in the Theory of Condensed Matter, Cavendish Laboratory, Cambridge
- 1995-1999: Lecturer, Cavendish Laboratory, Cambridge
- 1995-date: Fellow, St John’s College, Cambridge
- 1994-1995: Royal Society Research Fellow and Lecturer, Imperial College, London
- 1990-1991: Junior Research Fellow, Gonville and Caius College, Cambridge
Research
Ben is a member the Department of Applied Mathematics and Theoretical Physics and the Cavendish Laboratory, Department of Physics. He also holds affiliated positions in the Wellcome Trust/CRUK Gurdon Institute and the Wellcome Trust/MRC Stem Cell Institute. His research interests have spanned a wide range of topics within the area of theoretical quantum condensed matter physics. However, his current interests are focussed on the application of modelling approaches to study the dynamics of biological systems, from subcellular processes, to cell fate decision-making and morphogenic processes. His research is supported by grants from EPSRC, the Wellcome Trust, CRUK and the Royal Society.
Selected Publications
- S. Rulands, et al., Universality of clone dynamics during tissue development, Nature Physics 14, 469-474 (2018)
- E. Hannezo, et al., A unifying theory of branching morphogenesis, Cell 171, 242-255 (2017)
- X. Lan, et al., Cell fate mapping of human glioblastoma reveals an invariant stem cell hierarchy pre- and post-treatment, Nature 549, 227-232 (2017)
- A. Sanchez-Danes, et al., Defining the clonal dynamics leading to tumor initiation, Nature 536, 298-303 (2016)
- B. D. Simons and H. Clevers, Strategies of stem cell self-renewal in adult tissues, Cell 145, 851-862 (2011)
- C. Lopez-Garcia, et al., Intestinal stem cell replacement follows a pattern of neutral drift, Science 330, 822-825 (2010)
Publications
A single-cell molecular map of mouse gastrulation and early organogenesis.
– Nature
(2019)
566,
490
(doi: 10.1038/s41586-019-0933-9)
Constrained actin dynamics emerges from variable compositions of actin regulatory protein complexes
(2019)
(doi: 10.1101/525725)
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.
– Cell Stem Cell
(2019)
24,
79
(doi: 10.1016/j.stem.2018.11.013)
Single Cell RNA-Sequencing Reveals Plasmalemma Vesicle-Associated Protein (PLVAP) as a Novel Target with a Role in New Blood Vessel Formation in the Ischaemic Heart
– JOURNAL OF VASCULAR RESEARCH
(2019)
56,
103
Extreme value statistics of mutation accumulation in renewing cell populations
– Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
(2018)
98,
050401
(doi: 10.1103/physreve.98.050401)
Statistical theory of branching morphogenesis.
– Development Growth and Differentiation
(2018)
60,
512
(doi: 10.1111/dgd.12570)
Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells.
– Scientific Reports
(2018)
8,
15374
(doi: 10.1038/s41598-018-33838-5)
Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate.
– EMBO Journal
(2018)
38,
e99518
(doi: 10.15252/embj.201899518)
Cardelino: Integrating whole exomes and single-cell transcriptomes to reveal phenotypic impact of somatic variants
(2018)
(doi: 10.1101/413047)
Defining lineage potential and fate behavior of precursors during pancreas development
– Developmental cell
(2018)
46,
360
(doi: 10.1016/j.devcel.2018.06.028)
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