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Department of Applied Mathematics and Theoretical Physics

Career

  •  2018-date: Royal Society E.P. Abraham Professor, DAMPT, Cambridge
  • 2011-date: Herchel Smith Chair in Physics, Cavendish Laboratory,
  • Cambridge
  • 2002-2010: Personal Chair in the Theory of Condensed Matter, Cavendish Laboratory,
  • Cambridge
  • 2000-2002: University Readership in the Theory of Condensed Matter, Cavendish Laboratory, Cambridge
  • 1995-1999: Lecturer, Cavendish Laboratory, Cambridge
  • 1995-date: Fellow, St John’s College, Cambridge
  • 1994-1995: Royal Society Research Fellow and Lecturer, Imperial College, London
  • 1990-1991: Junior Research Fellow, Gonville and Caius College, Cambridge

Research

Ben is a member the Department of Applied Mathematics and Theoretical Physics and the Cavendish Laboratory, Department of Physics. He also holds affiliated positions in the Wellcome Trust/CRUK Gurdon Institute and the Wellcome Trust/MRC Stem Cell Institute. His research interests have spanned a wide range of topics within the area of theoretical quantum condensed matter physics. However, his current interests are focussed on the application of modelling approaches to study the dynamics of biological systems, from subcellular processes, to cell fate decision-making and morphogenic processes. His research is supported by grants from EPSRC, the Wellcome Trust, CRUK and the Royal Society.

Selected Publications

  • S. Rulands, et al., Universality of clone dynamics during tissue development, Nature Physics 14, 469-474 (2018)
  • E. Hannezo, et al., A unifying theory of branching morphogenesis, Cell 171, 242-255 (2017)
  • X. Lan, et al., Cell fate mapping of human glioblastoma reveals an invariant stem cell hierarchy pre- and post-treatment, Nature 549, 227-232 (2017)
  • A. Sanchez-Danes, et al., Defining the clonal dynamics leading to tumor initiation, Nature 536, 298-303 (2016)
  • B. D. Simons and H. Clevers, Strategies of stem cell self-renewal in adult tissues, Cell 145, 851-862 (2011)
  • C. Lopez-Garcia, et al., Intestinal stem cell replacement follows a pattern of neutral drift, Science 330, 822-825 (2010)

Publications

Early stem cell aging in the mature brain
A Ibrayeva, M Bay, E Pu, DJ Jörg, L Peng, H Jun, N Zhang, D Aaron, C Lin, G Resler, A Hidalgo, M-H Jang, BD Simons, MA Bonaguidi
– Cell stem cell
(2021)
28,
955
Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation.
U Dobramysl, IK Jarsch, Y Inoue, H Shimo, B Richier, JR Gadsby, J Mason, A Szałapak, PS Ioannou, GP Correia, A Walrant, R Butler, E Hannezo, BD Simons, JL Gallop
– Journal of Cell Biology
(2021)
220,
e202003052
Distinct progenitor behavior underlying neocortical gliogenesis related to tumorigenesis.
Z Shen, Y Lin, J Yang, DJ Jörg, Y Peng, X Zhang, Y Xu, L Hernandez, J Ma, BD Simons, S-H Shi
– Cell Reports
(2021)
34,
108853
Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids.
R Azzarelli, M Ori, A Philpott, BD Simons
– Biology open
(2021)
10,
bio056416
Behavior and lineage progression of neural progenitors in the mammalian cortex
Y Lin, J Yang, Z Shen, J Ma, BD Simons, S-H Shi
– Current Opinion in Neurobiology
(2021)
66,
144
Stem Cell Populations as Self-Renewing Many-Particle Systems
DJ Jorg, Y Kitadate, S Yoshida, BD Simons
(2021)
12,
135
Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging
S Bottes, BN Jaeger, G-A Pilz, DJ Jörg, JD Cole, M Kruse, L Harris, VI Korobeynyk, I Mallona, F Helmchen, F Guillemot, BD Simons, S Jessberger
– Nature Neuroscience
(2020)
24,
225
Stem Cell Populations as Self-Renewing Many-Particle Systems
DJ Jörg, Y Kitadate, S Yoshida, BD Simons
– Annual Review of Condensed Matter Physics
(2020)
12,
135
Highly multiplexed spatially resolved gene expression profiling of mouse organogenesis
T Lohoff, S Ghazanfar, A Missarova, N Koulena, N Pierson, JA Griffiths, ES Bardot, C-HL Eng, RCV Tyser, R Argelaguet, C Guibentif, S Srinivas, J Briscoe, BD Simons, A-K Hadjantonakis, B Göttgens, W Reik, J Nichols, L Cai, JC Marioni
(2020)
Tracing the cellular basis of islet specification in mouse pancreas.
MK Sznurkowska, E Hannezo, R Azzarelli, L Chatzeli, T Ikeda, S Yoshida, A Philpott, BD Simons
– Nature Communications
(2020)
11,
5037
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Research Group

Biological Physics and Mechanics

Room

H1.13

Telephone

01223 766833