
Personal Homepage: http://www.damtp.cam.ac.uk/user/sh753/index.html
Career
- 2021-present: Senior Research Associate, DAMTP, University of Cambridge
- 2013-2021: Postdoctoral researcher, DAMTP, University of Cambridge
- 2009-2013: Doctoral student, Department for Cellular and Developmental Biology of Plants, Bielefeld University, DE
- 2003-2009: Bachelor/Master student, Bielefeld University, DE
Research
How do cells generate the forces that shape our tissues and organs? In developing embryos, its cells move and change their shape in an astoundingly coordinated way. We need to understand the underlying mechanics, as errors in this self-organisation can lead to severe birth defects. Many tissues, including the primal gut, the neural tube and our retina, are formed through Cell Sheet Folding. I combine advanced imaging, mechanical perturbations, and computational modelling to reveal biophysical and mechano-chemical mechanisms underlying Cell Sheet Folding.
Publications
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PA Haas, SSMH Höhn. Cut it out: Out-of-plane stresses in cell sheet folding of Volvox embryos. Pys Rev E 111, 014420 (2025). DOI: https://doi.org/10.1103/PhysRevE.111.014420
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B vd Heyde, E vd Heyde, A Srinivasan, S Birwa, RE Goldstein, SSMH Höhn, A Hallmann. Spatiotemporal distribution of the glycoprotein pherophorin II reveals stochastic geometry of the growing ECM of Volvox carteri. accepted. https://www.biorxiv.org/content/10.1101/2024.12.06.625376v1
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A Srinivasan, SSMH Höhn, RE Goldstein. Stochastic Voronoi Tessellations as Models for Cellular Neighbourhoods in Simple Multicellular Organisms (2024), accepted. https://www.biorxiv.org/content/10.1101/2024.03.11.584390v1
- Thomas C. Day, SSMH Höhn, Seyed A. Zamani-Dahaj, David Yanni, Anthony Burnetti, Jennifer Pentz, Aurelia R. Honerkamp-Smith, Hugo Wioland, Hannah R. Sleath, William C. Ratcliff, Raymond E. Goldstein, and Peter J. Yunker. Cellular Organization in Lab-Evolved and Extant Multicellular Species Obeys a Maximum Entropy Law. eLife, in press. [OA]: https://www.biorxiv.org/content/10.1101/2021.07.29.454238v1
- Daniele Agostinelli, Robert Cerbino, Juan C. Del Alamo, Antonio DeSimone, SSMH Höhn, Cristian Micheletti, Giovanni Noselli, Eran Sharon and Julia Yeomans. MicroMotility: state of the art, recent accomplishments and perspectives on the mathematical modeling of bio-motility at microscopic scales. Mathematics in Engineering 2(2): 230 (2020).
[OA]: https://www.aimspress.com/article/10.3934/mine.2020011
- Pierre A. Haas*, SSMH Höhn*, Aurelia E. Honerkamp-Smith, Julius B. Kirkegaard and Raymond E. Goldstein. The noisy basis of morphogenesis: mechanisms and mechanics of cell sheet folding inferred from developmental variability. PLOS Biology 16, e2005536 (2018).
[OA]: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005536
* Equal contribution.
- SSMH Höhn and Armin Hallmann, Distinct shape-shifting regimes of bowl-shaped cell sheets – embryonic inversion in the multicellular green alga Pleodorina californica, BMC Developmental Biology, 16:35 (2016).
[OA]: https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861-016-0134-9
- SSMH Höhn, Aurelia E. Honerkamp-Smith, Pierre A. Haas, Philipp Khuc Trong, and Raymond E. Goldstein, Dynamics of a Volvox embryo turning itself inside out, Physical Review Letters 114, 178101 (2015).
[OA]: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.114.178101
See also Physics Viewpoint by A. Boudaoud, Physics 8, 39 (2015). https://physics.aps.org/articles/v8/39
- SSMH Höhn and Armin Hallmann. There is more than one way to turn a spherical cellular monolayer inside out: type B embryo inversion in Volvox globator, BMC Biology, 9:98 (2011).
[OA]: https://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-9-89
See also BMC Biology Commentary by R. Keller and D. Shook, BMC Biology, 9: 90 (2011). https://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-9-9