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Department of Applied Mathematics and Theoretical Physics

Career

  •  2018-date: Royal Society E.P. Abraham Professor, DAMPT, Cambridge
  • 2011-date: Herchel Smith Chair in Physics, Cavendish Laboratory,
  • Cambridge
  • 2002-2010: Personal Chair in the Theory of Condensed Matter, Cavendish Laboratory,
  • Cambridge
  • 2000-2002: University Readership in the Theory of Condensed Matter, Cavendish Laboratory, Cambridge
  • 1995-1999: Lecturer, Cavendish Laboratory, Cambridge
  • 1995-date: Fellow, St John’s College, Cambridge
  • 1994-1995: Royal Society Research Fellow and Lecturer, Imperial College, London
  • 1990-1991: Junior Research Fellow, Gonville and Caius College, Cambridge

Research

Ben is a member the Department of Applied Mathematics and Theoretical Physics and the Cavendish Laboratory, Department of Physics. He also holds affiliated positions in the Wellcome Trust/CRUK Gurdon Institute and the Wellcome Trust/MRC Stem Cell Institute. His research interests have spanned a wide range of topics within the area of theoretical quantum condensed matter physics. However, his current interests are focussed on the application of modelling approaches to study the dynamics of biological systems, from subcellular processes, to cell fate decision-making and morphogenic processes. His research is supported by grants from EPSRC, the Wellcome Trust, CRUK and the Royal Society.

Selected Publications

  • S. Rulands, et al., Universality of clone dynamics during tissue development, Nature Physics 14, 469-474 (2018)
  • E. Hannezo, et al., A unifying theory of branching morphogenesis, Cell 171, 242-255 (2017)
  • X. Lan, et al., Cell fate mapping of human glioblastoma reveals an invariant stem cell hierarchy pre- and post-treatment, Nature 549, 227-232 (2017)
  • A. Sanchez-Danes, et al., Defining the clonal dynamics leading to tumor initiation, Nature 536, 298-303 (2016)
  • B. D. Simons and H. Clevers, Strategies of stem cell self-renewal in adult tissues, Cell 145, 851-862 (2011)
  • C. Lopez-Garcia, et al., Intestinal stem cell replacement follows a pattern of neutral drift, Science 330, 822-825 (2010)

Publications

Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisions
FLAF Gomes, G Zhang, F Carbonell, JA Correa, WA Harris, BD Simons, M Cayouette
– Development (Cambridge, England)
(2010)
138,
227
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.
HJ Snippert, LG van der Flier, T Sato, JH van Es, M van den Born, C Kroon-Veenboer, N Barker, AM Klein, J van Rheenen, BD Simons, H Clevers
– Cell
(2010)
143,
134
Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift
C Lopez-Garcia, AM Klein, BD Simons, DJ Winton
– Science (New York, N.Y.)
(2010)
330,
822
Mouse germ line stem cells undergo rapid and stochastic turnover.
AM Klein, T Nakagawa, R Ichikawa, S Yoshida, BD Simons
– Cell Stem Cell
(2010)
7,
214
Quantum phase transitions in bosonic heteronuclear pairing Hamiltonians
M Hohenadler, AO Silver, MJ Bhaseen, BD Simons
– Physical Review A
(2010)
82,
013639
Collective dynamics of Bose-Einstein condensates in optical cavities.
J Keeling, MJ Bhaseen, BD Simons
– Phys Rev Lett
(2010)
105,
043001
Exciton front propagation in photoexcited GaAs quantum wells
S Yang, LV Butov, LS Levitov, BD Simons, AC Gossard
– Physical Review B Condensed Matter and Materials Physics
(2010)
81,
115320
Magnetic analog of the fulde-ferrell-larkin-ovchinnikov phase in Sr3 Ru2 O7
AM Berridge, SA Grigera, BD Simons, AG Green
– Physical Review B
(2010)
81,
054429
Bose-Hubbard models coupled to cavity light fields
AO Silver, M Hohenadler, MJ Bhaseen, BD Simons
– Physical Review A
(2010)
81,
023617
The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate
DP Doupé, AM Klein, BD Simons, PH Jones
– Dev Cell
(2010)
18,
317
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Research Group

Biological Physics and Mechanics

Room

H1.13

Telephone

01223 766833