A major frontier in cosmic microwave background (CMB) science is the study of secondary anisotropies—temperature and polarization anisotropies induced by the gravitational, electromagnetic, or beyond-standard-model (BSM) interactions of CMB photons with large-scale structure (LSS) over cosmic history. Leveraging their distinct statistical properties and cross-correlations with LSS enables us to isolate these secondary anisotropies from the primary CMB and extract new astrophysical and cosmological information. In this talk, I discuss how secondary anisotropies from electromagnetic interactions (Sunyaev-Zel’dovich effects) and hypothetical BSM particles (dark screening) can serve as probes of fundamental physics. I present a general formalism for capturing the information content of secondary anisotropies. I then give a summary of existing measurements of the kinetic Sunyaev-Zel’dovich (kSZ), polarized Sunyaev-Zel’dovich (pSZ), and dark screening effects. Next I provide an update on how these measurements constrain large-scale homogeneity, primordial non-Gaussianity, isocurvature, and BSM particles (axions and dark photons). Looking ahead to the high-resolution, low-noise, large-volume frontier, I discuss how upcoming observations from the Simons Observatory, combined with LSS surveys like DESI and LSST, will significantly improve these results and allow for novel tests of fundamental physics.