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Department of Applied Mathematics and Theoretical Physics


  •  2018-date: Royal Society E.P. Abraham Professor, DAMPT, Cambridge
  • 2011-date: Herchel Smith Chair in Physics, Cavendish Laboratory,
  • Cambridge
  • 2002-2010: Personal Chair in the Theory of Condensed Matter, Cavendish Laboratory,
  • Cambridge
  • 2000-2002: University Readership in the Theory of Condensed Matter, Cavendish Laboratory, Cambridge
  • 1995-1999: Lecturer, Cavendish Laboratory, Cambridge
  • 1995-date: Fellow, St John’s College, Cambridge
  • 1994-1995: Royal Society Research Fellow and Lecturer, Imperial College, London
  • 1990-1991: Junior Research Fellow, Gonville and Caius College, Cambridge


Ben is a member the Department of Applied Mathematics and Theoretical Physics and the Cavendish Laboratory, Department of Physics. He also holds affiliated positions in the Wellcome Trust/CRUK Gurdon Institute and the Wellcome Trust/MRC Stem Cell Institute. His research interests have spanned a wide range of topics within the area of theoretical quantum condensed matter physics. However, his current interests are focussed on the application of modelling approaches to study the dynamics of biological systems, from subcellular processes, to cell fate decision-making and morphogenic processes. His research is supported by grants from EPSRC, the Wellcome Trust, CRUK and the Royal Society.

Selected Publications

  • S. Rulands, et al., Universality of clone dynamics during tissue development, Nature Physics 14, 469-474 (2018)
  • E. Hannezo, et al., A unifying theory of branching morphogenesis, Cell 171, 242-255 (2017)
  • X. Lan, et al., Cell fate mapping of human glioblastoma reveals an invariant stem cell hierarchy pre- and post-treatment, Nature 549, 227-232 (2017)
  • A. Sanchez-Danes, et al., Defining the clonal dynamics leading to tumor initiation, Nature 536, 298-303 (2016)
  • B. D. Simons and H. Clevers, Strategies of stem cell self-renewal in adult tissues, Cell 145, 851-862 (2011)
  • C. Lopez-Garcia, et al., Intestinal stem cell replacement follows a pattern of neutral drift, Science 330, 822-825 (2010)


Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes.
DJ McCarthy, R Rostom, Y Huang, DJ Kunz, P Danecek, MJ Bonder, T Hagai, R Lyu, HipSci Consortium, W Wang, DJ Gaffney, BD Simons, O Stegle, SA Teichmann
– Nature methods
Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids.
N Georgakopoulos, N Prior, B Angres, G Mastrogiovanni, A Cagan, D Harrison, CJ Hindley, R Arnes-Benito, S-S Liau, A Curd, N Ivory, BD Simons, I Martincorena, H Wurst, K Saeb-Parsy, M Huch
– BMC Dev Biol
Tracing the Dynamics of Stem Cell Fate
L Chatzeli, B Simons
– Cold Spring Harbor Perspectives in Biology
Defining branching morphogenesis in murine salivary glands using a computational approach
Z Waheed, L Chatzeli, BD Simons
Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development.
TG Krieger, CM Moran, A Frangini, WE Visser, E Schoenmakers, F Muntoni, CA Clark, D Gadian, WK Chong, A Kuczynski, M Dattani, G Lyons, A Efthymiadou, F Varga-Khadem, BD Simons, K Chatterjee, FJ Livesey
– Proc Natl Acad Sci U S A
Defining the identity and dynamics of adult gastric isthmus stem cells
S Han, J Fink, DJ Jörg, E Lee, MK Yum, L Chatzeli, SR Merker, M Josserand, T Trendafilova, A Andersson-Rolf, C Dabrowska, H Kim, R Naumann, J-H Lee, N Sasaki, RL Mort, O Basak, H Clevers, DE Stange, A Philpott, JK Kim, BD Simons, B-K Koo
– Cell Stem Cell
Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states
MS Andersen, E Hannezo, S Ulyanchenko, S Estrach, Y Antoku, S Pisano, KE Boonekamp, S Sendrup, M Maimets, MT Pedersen, JV Johansen, DL Clement, CC Feral, BD Simons, KB Jensen
– Nature cell biology
Multiscale dynamics of branching morphogenesis.
E Hannezo, BD Simons
– Current opinion in cell biology
Single Cell Transcriptome Analyses Reveal Novel Targets Modulating Cardiac Neovascularisation by Resident Endothelial Cells Following Myocardial Infarction
Z Li, EG Solomonidis, M Meloni, RS Taylor, R Duffin, R Dobie, MS Magalhaes, BEP Henderson, PA Louwe, G D'Amico, KM Hodivala-Dilke, AM Shah, NL Mills, BD Simons, GA Gray, NC Henderson, AH Baker, M Brittan
– European Heart Journal
Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool.
N Prior, CJ Hindley, F Rost, E Meléndez, WWY Lau, B Göttgens, S Rulands, BD Simons, M Huch
– Development (Cambridge, England)
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Research Group

Biological Physics and Mechanics




01223 766833