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Department of Applied Mathematics and Theoretical Physics

Professor Ben Simons

Career

  •  2018-date: Royal Society E.P. Abraham Professor, DAMPT, Cambridge
  • 2011-date: Herchel Smith Chair in Physics, Cavendish Laboratory,
  • Cambridge
  • 2002-2010: Personal Chair in the Theory of Condensed Matter, Cavendish Laboratory,
  • Cambridge
  • 2000-2002: University Readership in the Theory of Condensed Matter, Cavendish Laboratory, Cambridge
  • 1995-1999: Lecturer, Cavendish Laboratory, Cambridge
  • 1995-date: Fellow, St John’s College, Cambridge
  • 1994-1995: Royal Society Research Fellow and Lecturer, Imperial College, London
  • 1990-1991: Junior Research Fellow, Gonville and Caius College, Cambridge

Research

Ben is a member the Department of Applied Mathematics and Theoretical Physics and the Cavendish Laboratory, Department of Physics. He also holds affiliated positions in the Wellcome Trust/CRUK Gurdon Institute and the Wellcome Trust/MRC Stem Cell Institute. His research interests have spanned a wide range of topics within the area of theoretical quantum condensed matter physics. However, his current interests are focussed on the application of modelling approaches to study the dynamics of biological systems, from subcellular processes, to cell fate decision-making and morphogenic processes. His research is supported by grants from EPSRC, the Wellcome Trust, CRUK and the Royal Society.

Selected Publications

  • S. Rulands, et al., Universality of clone dynamics during tissue development, Nature Physics 14, 469-474 (2018)
  • E. Hannezo, et al., A unifying theory of branching morphogenesis, Cell 171, 242-255 (2017)
  • X. Lan, et al., Cell fate mapping of human glioblastoma reveals an invariant stem cell hierarchy pre- and post-treatment, Nature 549, 227-232 (2017)
  • A. Sanchez-Danes, et al., Defining the clonal dynamics leading to tumor initiation, Nature 536, 298-303 (2016)
  • B. D. Simons and H. Clevers, Strategies of stem cell self-renewal in adult tissues, Cell 145, 851-862 (2011)
  • C. Lopez-Garcia, et al., Intestinal stem cell replacement follows a pattern of neutral drift, Science 330, 822-825 (2010)

Publications

Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states
MS Andersen, E Hannezo, S Ulyanchenko, S Estrach, Y Antoku, S Pisano, KE Boonekamp, S Sendrup, M Maimets, MT Pedersen, JV Johansen, DL Clement, CC Feral, BD Simons, KB Jensen
– Nat Cell Biol
(2019)
21,
924
(doi: 10.1038/s41556-019-0362-x)
Multiscale dynamics of branching morphogenesis
E Hannezo, BD Simons
– Current opinion in cell biology
(2019)
60,
99
(doi: 10.1016/j.ceb.2019.04.008)
Single Cell Transcriptome Analyses Reveal Novel Targets Modulating Cardiac Neovascularisation by Resident Endothelial Cells Following Myocardial Infarction
Z Li, EG Solomonidis, M Meloni, RS Taylor, R Duffin, R Dobie, MS Magalhaes, BEP Henderson, PA Louwe, G D'Amico, KM Hodivala-Dilke, AM Shah, NL Mills, BD Simons, GA Gray, NC Henderson, AH Baker, M Brittan
– Eur Heart J
(2019)
40,
2507
(doi: 10.1093/eurheartj/ehz305)
Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool
N Prior, CJ Hindley, F Rost, E Meléndez, WWY Lau, B Göttgens, S Rulands, BD Simons, M Huch
– Development (Cambridge, England)
(2019)
146,
dev174557
(doi: 10.1242/dev.174557)
Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon (vol 8, pg 940, 2014)
A-M Baker, B Cereser, S Melton, AG Fletcher, M Rodriguez-Justo, PJ Tadrous, A Humphries, G Elia, SAC McDonald, NA Wright, BD Simons, M Jansen, TA Graham
– Cell Rep
(2019)
27,
2524
(doi: 10.1016/j.celrep.2019.05.035)
Identification of a regeneration-organizing cell in the Xenopus tail
C Aztekin, T Hiscock, J Marioni, J Gurdon, B Simons, J Jullien
– Science
(2019)
364,
653
(doi: 10.1126/science.aav9996)
Tracing the origin of adult intestinal stem cells
J Guiu, E Hannezo, S Yui, S Demharter, S Ulyanchenko, M Maimets, A Jørgensen, S Perlman, L Lundvall, LS Mamsen, A Larsen, RH Olesen, CY Andersen, LL Thuesen, KJ Hare, TH Pers, K Khodosevich, BD Simons, KB Jensen
– Nature
(2019)
570,
107
(doi: 10.1038/s41586-019-1212-5)
Intratumoral genetic and functional heterogeneity in pediatric glioblastoma
M Hoffman, AH Gillmor, DJ Kunz, MJ Johnston, A Nikolic, K Narta, M Zarrei, J King, K Ellestad, NH Dang, FMG Cavalli, MM Kushida, FJ Coutinho, Y Zhu, B Luu, Y Ma, AJ Mungall, R Moore, MA Marra, MD Taylor, TJ Pugh, PB Dirks, D Strother, L Lafay-Cousin, AC Resnick, S Scherer, DL Senger, BD Simons, JA Chan, AS Morrissy, M Gallo
– Cancer Res
(2019)
79,
2111
(doi: 10.1158/0008-5472.can-18-3441)
1. Crypt fusion as a homeostatic mechanism in the human colon
A-M Baker, C Gabbutt, MJ Williams, B Cereser, N Jawad, M Rodriguez-Justo, M Jansen, CP Barnes, BD Simons, SA McDonald, TA Graham, NA Wright
– Gut
(2019)
68,
1986
(doi: 10.1136/gutjnl-2018-317540)
The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism.
DJ Jörg, EE Caygill, AE Hakes, EG Contreras, AH Brand, BD Simons
– Elife
(2019)
8,
e40919
(doi: 10.7554/elife.40919)
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Research Group

Biological Physics and Mechanics

Email

bds10@damtp.cam.ac.uk

Room

H1.13

Telephone

01223 766833

Study at Cambridge

About the University

Research at Cambridge