Career
- 2018-date: Royal Society E.P. Abraham Professor, DAMPT, Cambridge
- 2011-date: Herchel Smith Chair in Physics, Cavendish Laboratory,
- Cambridge
- 2002-2010: Personal Chair in the Theory of Condensed Matter, Cavendish Laboratory,
- Cambridge
- 2000-2002: University Readership in the Theory of Condensed Matter, Cavendish Laboratory, Cambridge
- 1995-1999: Lecturer, Cavendish Laboratory, Cambridge
- 1995-date: Fellow, St John’s College, Cambridge
- 1994-1995: Royal Society Research Fellow and Lecturer, Imperial College, London
- 1990-1991: Junior Research Fellow, Gonville and Caius College, Cambridge
Research
Ben is a member the Department of Applied Mathematics and Theoretical Physics and the Cavendish Laboratory, Department of Physics. He also holds affiliated positions in the Wellcome Trust/CRUK Gurdon Institute and the Wellcome Trust/MRC Stem Cell Institute. His research interests have spanned a wide range of topics within the area of theoretical quantum condensed matter physics. However, his current interests are focussed on the application of modelling approaches to study the dynamics of biological systems, from subcellular processes, to cell fate decision-making and morphogenic processes. His research is supported by grants from EPSRC, the Wellcome Trust, CRUK and the Royal Society.
Selected Publications
- S. Rulands, et al., Universality of clone dynamics during tissue development, Nature Physics 14, 469-474 (2018)
- E. Hannezo, et al., A unifying theory of branching morphogenesis, Cell 171, 242-255 (2017)
- X. Lan, et al., Cell fate mapping of human glioblastoma reveals an invariant stem cell hierarchy pre- and post-treatment, Nature 549, 227-232 (2017)
- A. Sanchez-Danes, et al., Defining the clonal dynamics leading to tumor initiation, Nature 536, 298-303 (2016)
- B. D. Simons and H. Clevers, Strategies of stem cell self-renewal in adult tissues, Cell 145, 851-862 (2011)
- C. Lopez-Garcia, et al., Intestinal stem cell replacement follows a pattern of neutral drift, Science 330, 822-825 (2010)
Publications
The Independent Probabilistic Firing of Transcription Factors: A Paradigm for Clonal Variability in the Zebrafish Retina.
– Dev Cell
(2015)
34,
532
(doi: 10.1016/j.devcel.2015.08.011)
Cell Competition Modifies Adult Stem Cell and Tissue Population Dynamics in a JAK-STAT-Dependent Manner.
– Developmental cell
(2015)
34,
297
(doi: 10.1016/j.devcel.2015.06.010)
Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium.
– Cell reports
(2015)
12,
90
(doi: 10.1016/j.celrep.2015.06.011)
Fluctuation and commensurability effect of exciton density wave
– Physical Review B Condensed Matter and Materials Physics
(2015)
91,
245302
(doi: 10.1103/PhysRevB.91.245302)
Dynamic stem cell heterogeneity.
– Development (Cambridge, England)
(2015)
142,
1396
(doi: 10.1242/dev.101063)
Deterministic progenitor behavior and unitary production of neurons in the neocortex.
– Cell
(2014)
159,
775
(doi: 10.1016/j.cell.2014.10.027)
Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development
– Nat Cell Biol
(2014)
16,
829
(doi: 10.1038/ncb3024)
Quantification of crypt and stem cell evolution in the normal and neoplastic human colon.
– Cell reports
(2014)
8,
940
(doi: 10.1016/j.celrep.2014.07.019)
Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina
– Development Cambridge
(2014)
141,
3472
(doi: 10.1242/dev.109892)
Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo.
– EMBO Journal
(2014)
33,
2295
(doi: 10.15252/embj.201387500)
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