Career
- 2018-date: Royal Society E.P. Abraham Professor, DAMPT, Cambridge
- 2011-date: Herchel Smith Chair in Physics, Cavendish Laboratory,
- Cambridge
- 2002-2010: Personal Chair in the Theory of Condensed Matter, Cavendish Laboratory,
- Cambridge
- 2000-2002: University Readership in the Theory of Condensed Matter, Cavendish Laboratory, Cambridge
- 1995-1999: Lecturer, Cavendish Laboratory, Cambridge
- 1995-date: Fellow, St John’s College, Cambridge
- 1994-1995: Royal Society Research Fellow and Lecturer, Imperial College, London
- 1990-1991: Junior Research Fellow, Gonville and Caius College, Cambridge
Research
Ben is a member the Department of Applied Mathematics and Theoretical Physics and the Cavendish Laboratory, Department of Physics. He also holds affiliated positions in the Wellcome Trust/CRUK Gurdon Institute and the Wellcome Trust/MRC Stem Cell Institute. His research interests have spanned a wide range of topics within the area of theoretical quantum condensed matter physics. However, his current interests are focussed on the application of modelling approaches to study the dynamics of biological systems, from subcellular processes, to cell fate decision-making and morphogenic processes. His research is supported by grants from EPSRC, the Wellcome Trust, CRUK and the Royal Society.
Selected Publications
- S. Rulands, et al., Universality of clone dynamics during tissue development, Nature Physics 14, 469-474 (2018)
- E. Hannezo, et al., A unifying theory of branching morphogenesis, Cell 171, 242-255 (2017)
- X. Lan, et al., Cell fate mapping of human glioblastoma reveals an invariant stem cell hierarchy pre- and post-treatment, Nature 549, 227-232 (2017)
- A. Sanchez-Danes, et al., Defining the clonal dynamics leading to tumor initiation, Nature 536, 298-303 (2016)
- B. D. Simons and H. Clevers, Strategies of stem cell self-renewal in adult tissues, Cell 145, 851-862 (2011)
- C. Lopez-Garcia, et al., Intestinal stem cell replacement follows a pattern of neutral drift, Science 330, 822-825 (2010)
Publications
Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change.
– Nat Cell Biol
(2014)
16,
615
(doi: 10.1038/ncb2963)
Mouse spermatogenic stem cells continually interconvert between equipotent singly isolated and syncytial states
– Cell Stem Cell
(2014)
14,
658
(doi: 10.1016/j.stem.2014.01.019)
Fermionic Superradiance in a Transversely Pumped Optical Cavity
– Phys Rev Lett
(2014)
112,
143002
The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation
– Gut
(2014)
64,
11
(doi: 10.1136/gutjnl-2013-306171)
Abstract 145: human keratinocytes have two distinct cell proliferation patterns on timelapse imaging in vitro with 8-cell microarrays revealing early molecular identifiers.
– Plastic & Reconstructive Surgery
(2014)
133,
160
Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging
– Nature
(2014)
507,
362
(doi: 10.1038/nature12972)
Live imaging of human keratinocytes reveals two modes of cell proliferation
– BRITISH JOURNAL OF SURGERY
(2014)
101,
5
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.
– EMBO Reports
(2013)
15,
62
(doi: 10.1002/embr.201337799)
Distinct fibroblast lineages determine dermal architecture in skin development and repair.
– Nature
(2013)
504,
277
(doi: 10.1038/nature12783)
STEM CELL RENEWAL THEORY TURNS 60
– Nature Reviews Molecular Cell Biology
(2013)
14,
754
(doi: 10.1038/nrm3706)
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