University of Cambridge  >  DAMTP  >  Goldstein Lab

 

Professor Raymond E. Goldstein FRS

Schlumberger Professor
of Complex Physical Systems

Fellow of Churchill College



Our research group focuses on understanding nonequilibrium phenomena in the natural world, with particular emphasis on biological physics. We strive for a holistic approach in which theory and experiment seamlessly coexist, in the best tradition of DAMTP. Members of the group include theoretical and experimental physicists, chemists, applied mathematicians and biologists, and we collaborate broadly with scientists from other departments in Cambridge and beyond. Undergraduates are welcome to join us, especially for summer projects.




NEW: The Institute of Physics has just published an overview of Biological Physics in the UK. Click here or download directly here.

Tigra Fader Sample #1 - Simple Slide Show Here is a collection of images from our recent research.

Much of our current research is involved with physical aspects of multicellularity. We are engaged in studies of collective dynamics, mixing, and transport in concentrated bacterial and algal suspensions, striving to understand the more general problem of interacting, self-propelled organisms. These issues touch on aspects of nonequilibrium statistical mechanics and fluid dynamics, but also have implications for specific biological phenomena such as quorum sensing. Of interest also is the role of flagella-driven flows in the evolutionary transition from unicellular to multicellular organisms (using the Volvocine green algae as a model lineage). Experimental methods include optical trapping, high-speed imaging, fluorescence microscopy, microfluidics, and particle imaging velocimetry. We use a variety of model organisms to study these processes (the bacterium B. subtilis, and algae such as Chlamydomonas and Volvox). Theoretical tools used vary from nonlinear PDEs, as in fluid mechanics and elasticity, to statistical physics and dynamical systems methods.

A second main thrust centres around understanding the dynamics of cytoplasmic streaming, the persistent circulation of the fluid contents of large eukaryotic cells driven by the collective dynamics of motor proteins. Discovered by Bonaventura Corti in 1774, streaming has been studied intensely for over two centuries, but many fundamental questions have remained unanswered with regard to how the fluid motion impacts on cellular metabolism, homeostasis, and mixing. Using the model organisms Chara corallina and Arabidopsis thaliana we are engaged in a comprehensive experimental study of fluid dynamical and transport issues associated with streaming, using techniques from microfluidics, electrophysiology, fluid dynamics and molecular biology. At the same time, we have been developing a theoretical understanding of the unusual transport phenomena that take place in these high Peclet number flows, with their often intriguing geometry. Some of these transport issues have implications for microfluidic applications. (Image at left is copyright 2008 National Academy of Sciences U.S.A.).

 

A separate line of investigation focuses on a broad class of problems in the natural world involving growth by precipitation. The classic example of this is provided by cave formations such as stalactites, stalagmites, and draperies. We have developed a successful free-boundary theory for the ideal shape of stalactites by combining chemical kinetics and fluid dynamics. A related synthesis of fluid mechanics, heat transfer, and solidification led to a theory for the shapes of dripping icicles. Remarkably, these shapes have the same mathematical form far from the tip. We are currently investigating the origin of the ripples so commonly found on them, along with the great variety of non-axisymmetric shapes found in nature.

Research in our group is closely related to that of several other groups within DAMTP, including the Institute for Theoretical Geophysics , with whom we collaborate on problems of natural pattern formation involved in solidification, and other fluid dynamicists within DAMTP and the G.K. Batchelor Fluid Dynamics Laboratory, interested in instabilities. We work closely with Professor T.J. Pedley in the Biological Fluid Dynamics Group on problems of microorganism dynamics and pattern formation, and have growing ties with the Biological and Soft Systems and Medical Physics efforts in the Cavendish laboratory. Finally, we collaborate with groups in biology, including Plant Sciences, Zoology, and Genetics.