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Department of Applied Mathematics and Theoretical Physics

Career

  • 1997-2000 Wellcome Trust Fellow in Mathematical Biology, Edinburgh
  • 2000-2001 Lecturer, School of Informatics, Edinburgh
  • 2001-2004 Wellcome Trust Travelling Fellowship, St Louis and Edinburgh
  • 2004-2006 Lecturer, DAMTP
  • 2006-2015 Senior Lecturer, DAMTP
  • 2015- Reader. DAMTP

Research

Stephen Eglen is a computational neuroscientist: he uses computational methods to study the development of the nervous system, using mostly the retina and other parts of the visual pathway as a model system. He is particularly interested in questions of structural and functional development:

Structural development: how do retinal neurons acquire their positional information within a circuit?

Functional development: what are the mechanisms by which neurons make contact with each other, to perform functioning circuits?

Selected Publications

Please see my publications page

Publications

Neuronal clustering and fasciculation phenotype in Dscam- and Bax-deficient mouse retinas.
PW Keeley, BJ Sliff, SCS Lee, PG Fuerst, RW Burgess, SJ Eglen, BE Reese
– Journal of Comparative Neurology
(2012)
520,
1349
Cellular Spacing: Analysis and Modelling of Retinal Mosaics
SJ Eglen
(2012)
365
Modeling developmental patterns of spontaneous activity
J Gjorgjieva, SJ Eglen
– Current Opinion in Neurobiology
(2011)
21,
679
Analysis of simultaneous multielectrode recordings with 4,096 channels: changing dynamics of spontaneous activity in the developing retina
MH Hennig, A Maccione, M Gandolfo, M Down, SJ Eglen, L Berdondini, E Sernagor
– BMC neuroscience
(2011)
12,
P296
Modeling developmental patterns of spontaneous activity.
J Gjorgjieva, SJ Eglen
– Current Opinion in Neurobiology
(2011)
21,
679
Self-organization in the developing nervous system: theoretical models.
SJ Eglen, J Gjorgjieva
– All Life
(2010)
3,
176
Burst-time-dependent plasticity robustly guides ON/OFF segregation in the lateral geniculate nucleus
J Gjorgjieva, T Toyoizumi, SJ Eglen
– PLoS Comput Biol
(2009)
5,
e1000618
A Multi-Component Model of the Developing Retinocollicular Pathway Incorporating Axonal and Synaptic Growth.
KB Godfrey, SJ Eglen, NV Swindale
– PLoS computational biology
(2009)
5,
e1000600
Theoretical models of spontaneous activity generation and propagation in the developing retina.
KB Godfrey, SJ Eglen
– Molecular BioSystems
(2009)
5,
1527
A quick guide to teaching R programming to computational biology students.
SJ Eglen
– PLoS Comput Biol
(2009)
5,
e1000482
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Research Group

Computational Biology

Room

G0.11