

Goldstein Lab
Teaching
Biological Physics and Complex Fluids (Part III, Michaelmas 2016)
Prof Raymond E. Goldstein FRS and Dr Eric Lauga
This course will provide an overview of the physical and mathematical description of both living
and synthetic smallscale complex systems. The range of subjects and approaches, from phenomenology
to detailed calculations, will be of interest to students from applied mathematics,
physics, and computational biology. The first half of the course will give an overview of the
fundamental physical process at play in biology. After an introduction to statistical mechanics,
the topics will include molecular interactions, polymers, elasticity, chemical dynamics, and dynamics.
The second part of the course will build on the first half and bridge the gap from the
microscopic physics to the continuum scale in order to describe in detail the flow of complex,
nonNewtonian fluids and the theory of phoretic motion relevant to colloidal science.
The material is for your private use. Please do not distribute.
PDFs of many articles are accessible via links below.
Lecture Schedule (all lectures in MR14 at 11:0012:00)
 719 October: REG  intro, molecular forces, fluctuations, elasticity
 21 October  2 November: EL  viscoelasticity
 416 November: REG  chemical kinetics, patterns
 1830 November: EL  phoretic motion, sensing
Lecture notes
Lecture notes
from the previous Part III course on Biological Physics will be useful as supplements to
REG's lectures:
Caveat emptor: these will surely contain a significant number of errors and typos  so please
let us know when you find them.
Examples Classes
 1: Wednesday, 26 October, 2016: MR11, CMS: 14:1516:15
 2: Monday, 7 November, 2016: MR12, CMS: 14:0016:00
 3: Monday, 21 November, 2016: MR12, CMS: 16:1518:15
 4: Thursday, 23 January, 2017: MR12, CMS: 14:0016:00
Examples Sheets
Handouts/Lectures from prior years
Supplementary Reading
The following is a collection of references (mostly from the primary literature)
for the main topics of the course. These are being added as the course progresses.
Below you find a list of books and topics which we recommend for reading.
Introductory Reading
 P. Nelson. Biological Physics. W.H. Freeman (2007).
 J.D. Murray. Mathematical Biology I. & II. Springer (2007, 2008).
 K. Dill & S. Bromberg. Molecular Driving Forces. Garland (2009).
 National Committee for Fluid Mechanics Films on "Rheological Behavior of Fluids"
and "Low Reynolds Number Flow" [link]
 D.V. Boger & K. Walters, Rheological Phenomena in Focus (1993 Elsevier).
Reading to complement course material
 B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts and P. Walter. Molecular Biology
of the Cell. 5th edition. Garland Science (2007).
 J.N. Israelachvili. Intermolecular and Surface Forces. 2nd edition.
Academic Press (1992).
 E.J.W. Verwey and J.Th.G. Overbeek.
Theory of the Stability of Lyophobic Colloids. Elsevier (1948).
 M. Doi and S.F. Edwards. The Theory of Polymer Dynamics. OUP (1986).
 A. Parsegian. Van der Waals Forces. CUP (2005).
 D. Andelman & W. Poon. Condensed Matter Physics in Molecular and Cell Biology.
Taylor & Francis (2006).
 H.C. Berg. Random Walks in Biology. Princeton University Press (1993).
 E. Schrödinger. What is Life? CUP (1992).
 M. Haw. Middle World. Macmillan (2006).
 J.B.S. Haldane: On Being the Right Size
van der Waals forces
 B.R. Holstein, "The van der Waals interaction,"
Am. J. Phys. 69, 441449 (2000).
 H.C. Hamaker, "The Londonvan der Waals attraction
between spherical particles,"
Physica 4, 10581072 (1937).
 B.M. Axilrod and E. Teller, "Interaction of the van
der Waals type between three atoms," J. Chem. Phys. 11, 299300 (1943).
 K.K. Mon, N.W. Ashcroft, and G.V. Chester,
"Core polarization and the structure of simple metals,"
Phys. Rev. B 19, 51035122 (1979).
DLVO Theory and Charged Membranes
 M. Winterhalter and W. Helfrich,
"Effect of surface charge on the curvature elasticity of membranes,"
J. Phys. Chem. 92, 68656867 (1988).
 H.N.W. Lekkerkerker,
"Contribution of the electric double layer to the curvature elasticity of charged
amphiphilic monolayers,"
Physica A 159, 319328 (1989).
 D.J. Mitchell and B.W. Ninham,
"Curvature elasticity of charged membranes,"
Langmuir 5, 11211123 (1989).
 R.E. Goldstein, A.I. Pesci, and
V. RomeroRochin,
"Electric double layers near modulated surfaces,"
Phys. Rev. A 41, 55045515 (1990).
 B. Duplantier, R.E. Goldstein, V.
RomeroRochin, and A.I. Pesci,
"Geometrical and topological aspects of electric double layers near curved surfaces,"
Phys. Rev. Lett. 65, 508511 (1990).
 C. Gutsche, U.F. Keyser, K. Kegler,
F. Kremer, and P. Linse, "Forces between single pairs of charged colloids in aqueous solutions,"
Phys. Rev. E 76, 031403 (2007).
Hydration Repulsion
Manning Condensation
Brownian Motion
Entropic Forces
Elastohydrodynamics
 K.E. Machin,
"Wave propagation along flagella,"
J. Exp. Biol. 35, 796806 (1958).
 C.H. Wiggins, D. Riveline, A. Ott, and R.E. Goldstein,
"Trapping and wiggling: elastohydrodynamics of driven microfilaments,"
Biophys. J. 74, 10431060 (1998).
 C. Levinthal and H.R. Crane,
"On the Unwinding of DNA,"
Proc. Natl. Acad. Sci. (USA) 42, 436438 (1956).
 C.W. Wolgemuth, T.R. Powers, and R.E. Goldstein,
"Twirling and Whirling: Viscous Dynamics of Rotating Elastic Filaments,"
Phys. Rev. Lett. 84, 16231626 (2000).
 R.E. Goldstein, T.R. Powers, and C.H. Wiggins,
"Viscous Nonlinear Dynamics of Twist and Writhe,"
Phys. Rev. Lett. 80, 52325235 (1998).
Buckling Filaments
 M. Elbaum, D.K. Fygenson, and A. Libchaber,
"Buckling Microtubules in Vesicles," Phys. Rev. Lett. 76, 40784081 (1996).
 D.K. Fygenson, J.F. Marko, and A. Libchaber,
"Mechanics of MicrotubuleBased Membrane Extension," Phys. Rev. Lett. 79, 44974500 (1997).
Chemoreception
Pattern Formation
Reviews
Research Papers
 A.M. Turing, "The chemical basis of morphogenesis,"
Phil. Trans. Roy. Soc. 237, 3772 (1952).
 Q. Ouyang and H.L. Swinney,
"Transition from a uniform state to hexagonal and striped turing patterns,"
Nature 352, 610612 (1991).
 K.J. Lee, W.D. McCormick, Q. Ouyang, and H.L. Swinney,
"Pattern formation by interacting chemical fronts," Science 261, 192194 (1993).
 R.E.Goldstein, D.M. Petrich, and D.J. Muraki,
"Interface proliferation and the growth of labyrinths in a reactiondiffusion system,"
Phys. Rev. E 53, 39333957 (1996).
Action Potentials
NonNewtonian Flows
Phoretic Motion
Swimming of Individual Organisms
